Therapeutics

TierraBlog-001_FromTargetstoTreatment.pdf

Evolving strategies and application of proteins and peptide therapeutics in cancer treatment. Biomed. Pharmacother. 163, 114832 (2023).

Seebacher, N. A., Stacy, A. E., Porter, G. M. & Merlot, A. M. Clinical development of targeted and immune based anti-cancer therapies. J. Exp. Clin. Cancer Res. 38, 1–39 (2019).

Rosano, G. L., Morales, E. S. & Ceccarelli, E. A. New tools for recombinant protein production in Escherichia coli: A 5-year update. Protein Sci. 28, 1412–1422 (2019).

Lu, R.-M. et al. Development of therapeutic antibodies for the treatment of diseases. J. Biomed. Sci. 27, 1–30 (2020).

Lv, D. et al. CancerProteome: a resource to functionally decipher the proteome landscape in cancer. Nucleic Acids Res. 52, D1155–D1162 (2024).

Hamerlik, P. et al. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J. Exp. Med. 209, 507–520 (2012).

Cieslewicz, M. et al. Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival. Proc. Natl. Acad. Sci. U. S. A. 110, 15919–15924 (2013).

Granier, C. et al. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. ESMO Open 2, e000213 (2017).

Mikalsen, T., Gerits, N. & Moens, U. Inhibitors of signal transduction protein kinases as targets for cancer therapy. Biotechnol. Annu. Rev. 12, 153–223 (2006).

Dondapati, S. K., Stech, M., Zemella, A. & Kubick, S. Cell-Free Protein Synthesis: A Promising Option for Future Drug Development. BioDrugs 34, 327–348 (2020).

Kintzing, J. R., Filsinger Interrante, M. V. & Cochran, J. R. Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment. Trends Pharmacol. Sci. 37, 993–1008 (2016).

Soon, T. N., Chia, A. Y. Y., Yap, W. H. & Tang, Y.-Q. Anticancer Mechanisms of Bioactive Peptides. Protein Pept. Lett. 27, 823–830 (2020).

Xie, M., Liu, D. & Yang, Y. Anti-cancer peptides: classification, mechanism of action, reconstruction and modification. Open Biol. 10, 200004 (2020).

Wang, L. et al. Therapeutic peptides: current applications and future directions. Signal Transduct. Target. Ther. 7, (2022).

Antibody therapeutics product data. The Antibody Society https://www.antibodysociety.org/antibody-therapeutics-product-data/ (2021).

Sifniotis, V., Cruz, E., Eroglu, B. & Kayser, V. Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation. Antibodies 8, 36 (2019).

Madani, A. et al. Large language models generate functional protein sequences across diverse families. Nat. Biotechnol. 41, 1099–1106 (2023).

From targets to treatments: insights from the cancer proteome

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